Trintellix Reviews - What Is It?
DO NOT BUY Trintellix!!! You Must Read This Review!
Fully Researched: Side Effects, Ingredients, Price, User Feedback and More!
Trintellix is a medication indicated for the treatment of major depressive disorder (MDD). Its efficacy was established in studies with the participation of adults including the elderly. The product has its own official website, but I am not satisfied with its scarce content. There is no information about the ingredients in the drug; however, the manufacturer does disclose all the adverse reactions that may occur while taking Trintellix. The company behind the product is not reputable and is badly known. It is located somewhere in the USA. Its exact address is not mentioned on the official website. To my mind, the product cannot be trusted. But let's have a look at its main ingredient.
Ingredients of Trintellix - Does It Really Work? Is It a Scam?
The main ingredient in Trintellix is Vortioxetine which is also known as Brintellix under its trade name. It is an atypical antidepressant made by Lundbeck and Takeda. In fact, Vortioxetine is a stimulator and a serotonin modulator that is used as a treatment for major depressive disorder. However, this component can be dangerous due to the great number of adverse effects, the most common of which are dizziness, diarrhea, nausea, dry mouth, vomiting, constipation, flatulence, and sexual dysfunction. The drug can be used alone or in combination with other antidepressants. In the latter case, it can be life-threatening because vortioxetine can lead to the serotonin syndrome. At the same time, this medication is effective only if used in high dose.
Vortioxetine reaches the highest concentration in plasma within 7 to 11 hours post-administration. Its terminal half-life is approximately 66 hours. It reaches steady-state plasma concentrations within two weeks and has no active metabolites. Speaking about the history of this drug, it is important to say that Vortioxetine was discovered at Lundbeck by the scientists who reported the synthesis and rationale for the medication in a 2011 paper. In this year, the compound was studied in clinical trials. In the course of the partnership between Lundbeck and Takeda, Takeda paid Lundbeck $40 million upfront for the development of the drug. He also promised $345 million in milestone payments. The drug was co-promote the in the US and Japan by these two companies. Lundbeck received a royalty on the sales. There was also another drug candidate, tedatioxetine.
In September 2013, Vortioxetine was approved by the U.S. FDA for the treatment of MDD in grown-ups and it was later approved in Europe too. This compound was previously trademarked as Brintellix in the USA, but on May 2, 2016, the FDA in this country approved another name for this drug, Trintellix. It was done in order to avoid confusion with Brilinta, the blood-thinning medication.
The mechanism of vortioxetine effect is not well studied, but it is thought to be linked to the improvement of serotonergic activity in the central nervous system through inhibition of the reuptake of serotonin. It is also known for other activities such as 5-HT1A receptor agonism and 5-HT3 receptor antagonism. It has not been established how these activities are connected with the vortioxetine's antidepressant effect. Although no clinical studied confirmed that Trintellix impairs driving performance, patients should beware of taking this psychoactive drug before getting engaged in such activities. There is high risk of adverse psychomotor or cognitive effects.
In general, Trintellix is a tablet for oral administration. It contains the beta polymorph of vortioxetine hydrobromide (HBr). Vortioxetine is a white powder that is a bit soluble in water. Each tablet of the product contains 6.355 mg, 12.71 mg, 19.065 mg, or 25.42 mg of vortioxetine HBr equivalent to 5 mg, 10 mg, 15 mg, or 20 mg of vortioxetine.
The inactive ingredients in the medication include microcrystalline cellulose, mannitol, hydroxypropyl cellulose, magnesium stearate, sodium starch glycolate. The film coating which consists of titanium dioxide, hypromellose, polyethylene glycol 400, iron oxide yellow (10 mg and 15 mg) and iron oxide red (5 mg, 15 mg, and 20 mg).
Customer Reviews - Does It Have Any Side Effects?
The manufacturer of Trintellix openly speaks about possible adverse reactions associated with the use of this product. The following adverse reactions are described on the drug's label. It may cause hypersensitivity, Serotonin syndrome, clinical worsening and suicide risk, abnormal bleeding, Hyponatremia and activation of mania and hypomania.
The safety of Trintellix was evaluated in the study with the participation of 4746 patients (18 years to 88 years of age). All of them were diagnosed with MDD. 2616 of those patients took Trintellix in 6 to 8 week (5 mg to 20 mg once daily). 204 patients took the drug in a 24 week to 64 week at doses of 5 mg to 10 mg once daily. 2586 patients took at least one dose of Trintellix. It was concluded that about 8% of patients experienced side effects. The most common adverse reaction was nausea.
Patients with major depressive disorder may face worsening of their condition that is expressed in suicidal behavior and unusual changes in behavior. The emergence of suicidality may occur in certain patients, including the elderly and children. This drug may increase the risk of developing depression, suicidal thinking and behavior. But let's have a look at the real users' testimonials about the use of the medication.
"I used to take Trintellix for many year for anxiety and mild depression. It was working well for me but this year I started noticing swings in my mood. My doctor suggests me to switch to some other medication. I am weighing all pros and cons"
"The first day I took Trintellix I felt dizzy and suffered from the upset stomach and severe headache. I was really confused because I felt very energetic and focused at the same time. I thought I would be able to tolerate the side effects but on the 4th day, everything changed. I got serious itching all over my body, short breath and increased heart rate"
"Trintellix is extremely expensive but I was ready to pay such money to feel better. But I felt so disappointed when I realized that it made me so much worse. I started suffering from anxiety attacks every day and my depression got worse"
Where To Buy Trintellix?
Trintellix can be bought from different resources online. Website IsraelPharm sells Brintellix (10mg, 28 Tablets) for $66. The pack of 15mg costs $116, 20mg is worth $132, while 5mg costs $39. You will not find it on Amazon or GNC.
My Final Summary
Summing up, it is necessary to say that Trintellix is a very dangerous antidepressant pill which can make you feel even worse than ever, according to numerous users' reviews. For this reason, I cannot recommend this drug to usage. Another disadvantage is its high price which makes the product inaccessible for many patients. It is wiser to look for another medication that would be efficient and free from side effects.